Chicken and Spinach Casserole with Cream Cheese is a cozy, creamy dish that brings together tender chicken, fresh spinach, and rich cream cheese all baked into a warm, comforting meal. The creamy texture of the cheese blends perfectly with the savory chicken and vibrant greens, making it a great choice for any dinner when you want something both simple and flavorful.
I love making this casserole because it feels like a little bit of comfort food magic in one dish. It’s super easy to prepare, and I usually find myself adding a pinch of garlic or some shredded cheese on top for an extra tasty touch. The cream cheese melts down to create a smooth sauce that holds everything together nicely, and the spinach adds a fresh pop of color and nutrients that I always appreciate.
My favorite way to enjoy this casserole is straight from the oven with a side of crusty bread or a light salad. It’s one of those meals that’s great for feeding family or friends since it’s filling but still feels a bit special. Whenever I make it, I feel like I’m sharing a little home-cooked love through every bite, and that’s why it’s become one of our go-to dishes for busy weeknights or casual get-togethers.
Key Ingredients & Substitutions
Chicken breasts: Boneless, skinless chicken works best here for even cooking and tenderness. You can swap in chicken thighs if you want juicier meat, just adjust the cooking time a bit.
Spinach: Fresh spinach gives a bright flavor, but frozen spinach is a convenient, budget-friendly option. Just make sure to thaw and drain it well so the casserole isn’t watery.
Cream cheese: This is the star for the creamy texture. If you want to lighten it up, try using a low-fat cream cheese or replace some cream cheese with Greek yogurt for tanginess and protein.
Cheeses: Mozzarella adds gooey meltiness, while Parmesan provides a nice salty finish. You can swap mozzarella with provolone or cheddar for a different taste, and Parmesan with Pecorino Romano if you want more sharpness.
Heavy cream: Makes the sauce rich and smooth. Half-and-half is a good lighter substitute, or use coconut cream for a dairy-free option with a subtle twist.
How Can I Make Sure the Chicken Stays Juicy and Tender?
To keep chicken moist in this casserole, sear it first—this locks in juices and adds flavor. Don’t overcook during searing; just brown both sides. The chicken finishes cooking in the oven with the creamy sauce, which helps it stay tender.
- Heat the skillet and oil until hot before adding chicken to get a good sear.
- Sear on medium heat for 3-4 minutes per side until golden, not cooked through.
- Use a meat thermometer when baking — aim for 165°F (75°C) internal temperature.
- Let the casserole rest a few minutes after baking; this helps the juices redistribute.
Equipment You’ll Need
- Large skillet – I like using a skillet with a lid for searing chicken and cooking spinach easily.
- Mixing bowls – for combining the cream cheese mixture and preparing ingredients.
- Casserole dish – a 9×13 inch dish is perfect for baking everything evenly.
- Meat thermometer – helps check that the chicken is cooked to the safe 165°F (75°C).
- Cooking spoon and tongs – for flipping and mixing the chicken and spinach.
Flavor Variations & Add-Ins
- Swap mozzarella for Monterey Jack or cheddar to change up the flavor and meltiness.
- Add cooked bacon bits or sun-dried tomatoes for extra savory bites.
- Use Greek yogurt instead of some of the cream cheese for a tangy, lighter sauce.
- Mix in sliced mushrooms, bell peppers, or olives to boost veggies and flavor.
Chicken and Spinach Casserole with Cream Cheese
Ingredients You’ll Need:
- 4 boneless, skinless chicken breasts
- 8 oz fresh spinach (or frozen, thawed and drained)
- 8 oz cream cheese, softened
- 1 cup shredded mozzarella cheese
- ½ cup grated Parmesan cheese
- 1 cup heavy cream or half-and-half
- 2 cloves garlic, minced
- 2 tbsp olive oil or butter
- 1 tsp dried Italian seasoning (or mix of basil, oregano, thyme)
- Salt and pepper to taste
- Optional: crusty bread for serving
How Much Time Will You Need?
This casserole takes about 15 minutes of prep time and 25-30 minutes to bake, so you’ll have dinner ready in around 45 minutes total. It’s a perfect quick-cooking comfort meal!
Step-by-Step Instructions:
1. Prepare and Sear the Chicken:
Start by heating your oven to 375°F (190°C). Season the chicken breasts with salt, pepper, and half of the Italian seasoning. Then heat olive oil or butter in a large skillet over medium heat. Add the chicken and cook 3-4 minutes per side, just until golden but not fully cooked through. Remove from heat and set aside.
2. Cook the Spinach and Garlic:
In the same skillet, toss in the minced garlic and cook until you can smell its aroma, about one minute. Next, add your fresh or thawed spinach and cook until wilted or heated through. Don’t forget to season with a bit of salt and pepper.
3. Mix the Cream Cheese Sauce:
In a bowl, blend the softened cream cheese with the heavy cream, the remaining Italian seasoning, half of the mozzarella cheese, and half of the Parmesan cheese. Stir until the sauce turns creamy and smooth. Then fold in the spinach and garlic mixture you just cooked.
4. Assemble the Casserole:
Grease a casserole dish and place your seared chicken breasts evenly in the dish. Pour the creamy spinach mixture over the chicken, spreading it out so every piece gets covered. Sprinkle the remaining mozzarella and Parmesan cheese on top.
5. Bake and Serve:
Bake the casserole uncovered for 25-30 minutes, until the chicken is cooked through and the top looks golden and bubbly. Let it rest a few minutes before serving. For extra yum, serve with toasted crusty bread to soak up all that creamy goodness.
Can I Use Frozen Spinach Instead of Fresh?
Yes! Just be sure to thaw the frozen spinach completely and squeeze out any excess water before using it. This helps prevent your casserole from becoming watery.
How Do I Store Leftovers?
Store any leftover casserole in an airtight container in the fridge for up to 3 days. Reheat gently in the oven or microwave until warmed through.
Can I Make This Recipe Ahead of Time?
Absolutely! Prepare and assemble the casserole, then cover and refrigerate it for up to 24 hours before baking. Add a few extra minutes to the baking time if baking straight from the fridge.
What Can I Serve with This Casserole?
This dish pairs wonderfully with crusty bread, a simple green salad, or even a side of roasted vegetables for a complete meal.
